Academic Staffs

Academic Staff  | Supporting Staff

Name: ประเสริฐ โศภน, Ph.D., ศาสตราจารย์
Title: Professor Dr.
Education: Ph.D. (University of Wisconsin-Madison), USA
Expertise: • Crustacean,Mollusk and Echinodern Reproductive Biology and Neuroendocrimology
  • Cells and Molecular Biology of Fasciolosis and Schistosomiasis
  • Endometriosis  
Contact Address: Department: Anatomy  
  Room: B 112
  
  Lab: B 101
  Phone: +66 2201 5406
  E-Mail: prasert.sob@mahidol.ac.th
     
FULL CV    
Research Interest and ResearchExperience
  • Cell and Tissue Biology :
    1. Ultrastructure and cytochemistry of lymphoid and hematopoietic tissues.
    2. Ultrastructure of the kidney in normal and pathological states
    3. Pharmacological and nutraceutical benefits of extracts from the sea cucumber,Holothuria scabra.
    4. Stem cell , cancer biology,endometriosis.
  • Reproductive Biology :
    1. Spermatogenesis in normal and vitamin-A-deficient states.
    2. Structure of chromatin and basic nuclear proteins in mammalian male germ cells.
    3. Structure and biochemistry of mammalian eggs and embryonic development.
    4. Reproductive biology and culturing of frogs.
    5. Selection, cultivation and reproductive biology of economically-important aquatic mollusks and crustaceans.
    6. Development of aquaculture system for the sea cucumber, Holothuria scabra, and the application of reproductive hormones to enhance its productivity.
  • Cells and Molecular Biology of Parasites :
    1. Ultrastructure, biochemistry, immunochemistry of the tegument, and characterization of antigens characterization of antigens with immunodiagnostic and vaccine potentials in schistosomes, opisthorchis, fasciola and filaria.
    2. Developments of immunodiagnostic assays  vaccines and drugs for the above-mentioned parasitic diseases.
    3. Diseases of economic aquatic mollusks, crustaceans and sea cucumber.
 
Education:        
Year Degree Place
1966 B.Sc. (Human Biology) The University of Western Australia, Australia
1970 Ph.D. (Cell Biology & Anatomy) The University of Wisconsin, U.S.A.
 
Work Experiences and Training:                                 
Year  Detail
1975 Post-doctoral Study University of California at Los Angeles, U.S.A.
  Cell Biology and Electron Microscopy  
1983 WHO Visiting Scientist   Schistosome Membrane (Division of
    Parasitology,-  National Institute for
    Medical Research, The Ridgeway, Mill Hill,
    London, U.K.),
 
GRANT AND FELLOWSHIP SUPPORT:
  1. Ford Foundation (Grant #70-0609): Structure of Chromatin and Basic Nuclear Proteins in Mammalian Male Germ Cells,US$78,000, October 1978-September 1981. (P.I.)
  2. UNDP / World Bank / WHO Special Programme for Research and Training in Tropical Diseases (TDR #810148): Changes in the Structural and Biochemical Compositions of the Tegument and the Glycocalyx of Schistosoma japonicum and Schistosoma mekongi during Development, US$44,530, May 1982-April 1984. (P.I.)
  3. The Rockefeller Foundation: The Effect of Gossypol on the Structure of Chromatin and the Metabolism of Mammalian Male Germ Cells, US$26,000, May 1982-April 1984. (P.I.)
  4. UNDP / World Bank / WHO Special Programme for Research and Training in Tropical Diseases (TDR #840187): Ultrastructural, Biochemical and Immunochemical Studies of the Tegument of Schistosoma japonicum (Chinese & Philippine) and Schistosoma mekongi, US$76,992, August 1984-August 1987. (P.I.)
  5. USAID /SCI PSTC (Grant #936-5542-G-00-6076-00): Identification of Surface Antigens and Production of Monoclonal Antibodies in Schistosoma japonicum, US$150,000, August 1986-August 1989. (P.I.)
  6. Grant from the National Center for Genetic Engineering and Biotechnology: Strain Selection and Cultivation of Terrestrial Snails, US$30,000, July 1986-July 1989. (Co.P.I.)
  7. USAID /SCI PSTC (Grant #936-5542-G-00-7030-00): Early Detection of Lymphatic Filariasis and Attempt at Defining Protective Antigens, US$149,930, February 1987-February 1990. (Co.P.I.)
  8. UNDP / World Bank / WHO Special Programme for Research and Training in Tropical Diseases (TDR #870519): Organization and Function of Cytoskeleton in the Tegument of S. japonicum and S. mekongi and its response to Praziquantel, US$68,300, February 1988-February 1991. (P.I.)
  9. National Science and Technology Development Agency (CPT 89B-1-05-173): Development of Immunodiagnostic Assays for Circulating Fasciola gigantica Antigens Using Monoclonal Antibodies, US$250,000, June 1992-June 1995. (P.I.)
  10. National Science and Technology Development Agency (CPT 89B-1-05-175): Selection of Strains and Improvement of Reproduction of Frogs Through Biotechnology Methods, US$240,000, June 1992-June 1995. (Co.P.I.)
  11. Thailand Research Fund: Studies of the Structure, Roles and Relationships between the Nervous and Reproductive Systems of a Tropical Abalone, Haliotis asinina Linnaeus, US$92,000, January 1997-December 1998. (P.I.)
  12. National Science and Technology Development Agency: Characterization of Antigens in Fasciola gigantica for Development of Vaccine and Improved Immunodiagnosis, US$176,900, January 1997-June 1999. (Co.P.I.)
  13. Thailand Research Fund-Senior Research Scholar Fellowship: "Structural Organization of Chromatin in Male Germ Cells of Vertebrate and Invertebrate" and "Characterization of Fasciola gigantica antigens with vaccine potentials, and their syntheses at cellular level", US$250,000, December 1997-November 2000. (P.I.)
  14. Thailand Research Fund-Senior Research Scholar Fellowship : “Immunopathobiology, syntheses, and characterization of Fasciola gigantica antigens and encoding genes with diagnostic and vaccine potential” and “Neuroendocrine controls of gametogenesis and spawning in a tropical abalone, Haliotis asinina”, US$ 170,000, August 2001-July 2004 (P.I.)
  15. National Science and Technology Development Agency : Natural and in vitro fertilization of the giant tiger shrimp Penaeus monodon, US$ 140,000, January 2002-December 2004 (Co.P.I.)
  16. Thailand Research Fund-Senior Scholar Fellowship:Endocrine Manipulation of the Reproduction in the Tropical Abalone,Haliotis asinina,and the giant fresh water prawn, Macrobrachium rosenbergii,US$150,000,September 2004 –August,2007(P.I.)
  17. National Research Council / Mahidol University: Basic and Applied Studies of Hormone Controlling Reproduction and Growth of the Tropical Abalone, Haliotis asinina,and Cryopreservation of its Gametes for in Vitro Fertilization, US$170,000, October, 2004-October, 2007 (P.I.)
  18. สำนักงานคณะกรรมการการอุดมศึกษา: การกระตุ้นการสืบพันธุ์ การลอกคราบ และการเปลี่ยนแปลงเพศของกุ้งและปู เพื่อเพิ่มผลผลิตด้วยการควบคุมประสาทฮอร์โมน, 7.5 ล้านบาท, 2006-2008 (P.I.)
  19. Mahidol University: Development of diagnosis vaccine and drugs for protection and therapeutics against fasciolosis by Fasciola gigantica, 6 ล้านบาท, 2008-2010 (P.I.)
  20. Distinguished Research Professor(Thailand Research Fund,Commission on Higher Education,Mahidol University): Characterizations and relationships of gonadotropin-releasing hormones(GnRHs), gonadotropin hormones(GTHs),sex-promoting pheromones in crustaceans, and their possible applications in aquaculture. 9,000,000 bahts, 2009-2012(P.I.)
  21. Commission on Higher Education-Mahidol University Project on Research University: Selection of broodstocks of Macrobrachium rosenbergii that exhibit high growth and reproductive performance in response to feeds containing highly unsaturated fatty acids (HUFA).3,000,000 bahts,2011-2013.(P.I.)
  22. Agricultural Research Development Agency :Screening for Pharmacological and Nutraceutical Benefits of Extracts from the Sea Cucumber, Holothuria scabra,4,900,000bahts,2013-2016.(P.I.)
  23. Agricultural  Research Development  Agency: Development of aquaculture system for the sea cucumber, Holothuria scabra, Jaeger 1833, and the application of reproductive hormones to enhance its productivity, 8,600,000 bahts, 2013-2016 (Co.P.I.)  
    P.I.= Principal Investigator
    Co.P.I =Co-Principal Investigator
 
RESEARCH PUBLICATIONS:
  1. Kruangkum, T., Chotwiwatthanakun, C., Tinikul, Y., Hanna, P.J., Sobhon, P., Wanichanon, C. (2012). Distribution of serotonin and gamma-amino butyric acid immunoreactivity in the deutocerebrum of the male giant freshwater prawn, Macrobrachium rosenbergii The 2nd International Anatomical Science and Cell Biology Conference (IASCBC2012) & 36th Annual Conferences of Anatomy Association of Thailand, 6th - 8th December, 2012, Chiang Mai, Thailand. p.186.
  2. Sobhon, P., Chansela, P., Setou, M., Wanichanon, C., Hanna, P.J., Tinikul, Y., Poljaroen, J., Poomtong, T., Senin, N., Tamtin, M., Chaisri, C., Engsusophon, A., Sumpaonon, C. (2012). Stimulation of ovarian maturation and egg production in female broodstocks of the giant freshwater prawn, Macrobrachium rosenbergii, by feed enriched with polyunsaturated fatty acids. The 2nd International Anatomical Science and Cell Biology Conference (IASCBC2012) & 36th Annual Conferences of Anatomy Association of Thailand, 6th - 8th December, 2012, Chiang Mai, Thailand. p.448.
  3. Siangcham, T., Chansela, P., Hayasaka, T., Masaki, N., Sroyraya, M., Poljaroen, J., Suwansa-ard, S., Engsusophon, A., Hanna, P.J., Sobhon, P., Setou, M. (2013). Imaging Mass Spectrometry Reveals the Changes of Lipids and Fatty Acids during the Testes Maturation among Three Male Morphotypes of Macrobrachium rosenbergii. RGJ-Ph.D. Congress XIV, 5th -7th April, 2013, Pattaya, Thailand.
  4. Sobhon, P., Sroyraya, M., Songkoomkrong, S., Poljaroen, J., Changklungmoa, N., Hanna, P.J., Wongkularb, A., Weerakiet, S. (2014). Endometriosis: pathogenesis and possible chemo-therapeutic interventions. 37th AAT Annual Conferences of Anatomy Association of Thailand, 7th – 9th May, 2014, Phitsanulok, Thailand. P. 1.
  5. Sangpairoj, K., Changklungmoa, N., Apisawetakan, S., Sobhon, P., Chaithirayanon, K. (2014). Biochemical and bioactive properties of peroxiredoxin protein from Fasciola gigantica. 37th AAT Annual Conferences of Anatomy Association of Thailand, 7th – 9th May, 2014, Phitsanulok, Thailand. P. 152.
  6. Sangpairoj, K., Apisawetakan, S., Vivithanaporn, P., Chongthammakun, S., Sobhon, P., Chaithirayanon, K. (2014). Transcriptional inactivation effects of RUNX1 mRNA for metastatic and angiogenic-regulating genes in human glioma. 37th AAT Annual Conferences of Anatomy Association of Thailand, 7th – 9th May, 2014, Phitsanulok, Thailand. P. 153.
  7. Pranweerapaiboon, K., Chaithirayanon, K., Sroyraya, M., Tinikul, R., Poomthong, T., Hanna, P.J., Sobhon, P. (2014). An extract from the sea cucumber, Holothuria scabra, mediates anti-inflammatory activity of RAW264.7 murine macrophages. 37th AAT Annual Conferences of Anatomy Association of Thailand, 7th – 9th May, 2014, Phitsanulok, Thailand. P. 156.
  8. Chaiyamoon, A., Nontunha, N., Tinikul, Y., Tinikul, R., Poljaroen, J., Poomthong, T., Chaichotranunt, S., Pradit, W., Suwanmala, J., Hanna, P.J., Sobhon, P. (2014). The exiatence and distribution of GnRH-Like peptides in the central nervous system and ovaries of the sea cucumber, Holothuria scabra. 37th AAT Annual Conferences of Anatomy Association of Thailand, 7th – 9th May, 2014, Phitsanulok, Thailand. P. 162.
  9. Senarai, T., Vanichviriyakit, R., Weerachatyanukul, W., Sobhon, P., Sretarugsa, P. (2014). Sperm maturation and capacitation-like event in the blue swimming crab, Portunus pelegicus. 37th AAT Annual Conferences of Anatomy Association of Thailand, 7th – 9th May, 2014, Phitsanulok, Thailand. P. 168.
  10. Nontunha, N., Chaiyamoon, A., Poljaroen, J., Tinikul, Y., Tinikul, R., Poomthong, T., Chaichotranunt, S., Pradit, W., Suwanmala, J., Hanna, P.J., Wanichanon, C., Suphamungmee, W., Sobhon, P. (2014). Classification of differentiating male germ cells during reproductive cycle in the sea cucumber, Holothuria scabra (Jaeger 1833). 37th AAT Annual Conferences of Anatomy Association of Thailand, 7th – 9th May, 2014, Phitsanulok, Thailand. P. 252.